PIs are advised that NIH is making changes to the grant application form and guidelines for submissions due on or after May 25, 2020. Changes principally affect PHS human subjects and clinical trials information.
A high-level summary is available here.
https://grants.nih.gov/grants/electronicreceipt/files/high-level-form-change-summary-FORMS-F.pdf
Application form instructions are available here.
https://grants.nih.gov/grants/how-to-apply-application-guide.html