The NAM group is involved in MOLECULAR DATA STORAGE projects. Scroll down for more details!
dNAM
digital Nucleic Acid Memory (dNAM) is an alternative to sequencer-based DNA memory. In dNAM, data is encoded by selecting combinations of single-stranded DNA with (1) or without (0) docking-site domains on DNA origami breadboards. Information encoded into origami is read by monitoring the binding of fluorescent imager probes using DNA-PAINT super-resolution microscopy. As a prototype, a small message is encoded using fifteen origami structures. An error-correction algorithm fully recover the message when individual docking sites, or entire origami, are missing. Unlike other approaches to DNA-based data storage, reading dNAM does not require sequencing. As such, it offers an additional path to explore the advantages and disadvantages of DNA as an emerging memory material.
dNAM
digital Nucleic Acid Memory (dNAM) is enabled by the synergistic relationship of four main steps. Encoding where data is first converted in a binary string and then in localization points on the matrix. Writing where the matrix designs are assembled in DNA origami platforms. Reading where the matrices patterns are read-out using DNA-PAINT Super Resolution Microscopy. Decoding where the patterns images are post-processed trough a error correction algorithm to enable 100% retrieval of the original message.