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Publications

  1. Nikitina N, Wadsworth J, Goelzer M, Goldfeldt M, Bursa N, Howard S, Crandall C, Semodji A, Zavala AG, Judex S, Rubin J, Lujan TJ, Fitzp,trick CK, Rubin CT, Satici A, Uzer G. Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain. bioRxiv. 2025 Apr 11; PubMed Central PMCID: PMC12026902.
  2. Goelzer M, Howard S, Zavala AG, Conway D, Rubin J, Uzer G. Depletion of SUN1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis. Commun Biol. 2025 Mar 13;8(1):428. PubMed Central PMCID: PMC11906923.
  3. Regner AM, DeLeon M, Gibbons KD, Howard S, Nesbitt DQ, Darghiasi SF, Lujan TJ, Fitzpatrick CK, Farach-Carson MC, Wu D, Uzer G. Increased deformations are dispensable for cell mechanoresponse in engineered bone analogs mimicking aging bone marrow. Mechanobiology in Medicine. 2025; 100097, PubMed Central PMCID: PMC10614733.
  4. Semodji AM, Everingham JB, Hollar KA, Siegel DN, Jamison SE, Wilder FR, Uzer G, Lujan TJ. A multiaxial bioreactor system that applies targeted magnitudes of strain energy to 3D cellular constructs. J Mech Behav Biomed Mater. 2025 Mar 24;168:106983. PubMed PMID: 40222321.
  5. Birks S, Howard S, Wright CS, O’Rourke C, Day EA, Lamb AJ, Walsdorf JR, Lau A, Thompson WR, Uzer G. Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running. PLoS One. 2024;19(11):e0307816. PubMed Central PMCID: PMC11578491.
  6. Pancheri NM, Daw JT, Ditton D, Schiele NR, Birks S, Uzer G, Jones CL, Penney BT, Theodossiou SK. The LINC Complex Regulates Tendon Elastic Modulus, Collagen Crimp, and Lateral Expansion During Early Postnatal Development. J Orthop Res. 2025 Mar 16; PubMed PMID: 40089904.
  7. Birks S, Howard S, O’Rourke C, Thompson WR, Lau A, Uzer G. Osterix-driven LINC complex disruption in vivo diminishes osteogenesis at 8 weeks but not at 15 weeks. J Orthop Res. 2024 Apr 11; PubMed PMID: 38602438; NIHMSID: NIHMS1983384.
  8. Sen B, Xie Z, Thomas MD, Pattenden SG, Howard S, McGrath C, Styner M, Uzer G, Furey TS, Rubin J. Nuclear actin structure regulates chromatin accessibility. Nat Commun. 2024 May 15;15(1):4095. PubMed Central PMCID: PMC11096319.
  9. Khan O, Gasperini W, Necessary C, Jacobs Z, Perry S, Kuehl P, Nelson K, Gamble P, DeLeon M, Howard S, Zavala A, Farach-Carson MC, Blaber E, Wu D, Satici A, Uzer G, Development and characterization of a low intensity vibrational system for microgravity studies. NPJ Microgravity . 2024. PubMed Central PMCID: PMC10690179.
  10. Nikitina N, Bursa N, Goelzer M, Goldfeldt M, Crandall C, Howard S, Rubin J, Satici A, Uzer G. Data driven and cell specific determination of nuclei-associated actin structure. Small Structures, doi.org/10.1002/sstr.202300204,  2024
  11. Chan ME, Strait L, Ashdown C, Pasumarthy S, Hassan A, Crimarco S, Singh C, Patel VS, Pagnotti G, Khan O, Uzer G, Rubin CT. Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields. Mechanobiology in Medicine. 2024; 2 (4), 100080; PubMed Central PMCID: PMC10350023.
  12. Crandall C, Nikitina N, Zavala A, Howard S, Uzer G. Low-intensity vibration does not induce changes in microtubule dynamics in vitro. bioRxiv. 2024 March 23; doi: 10.1101/2024.03.20.585904.
  13. Yu CY, Mannen EM, Lujan TJ, Uzer G, Upasani V, Edmonds EW, Fitzpatrick CK. Porcine computational modeling to investigate developmental dysplasia of the hip. J Orthop Res. 2024 Apr 22; PubMed PMID: 38650103.
  14. McGrath C, Little-Letsinger SE, Pagnotti GM, Sen B, Xie Z, Uzer G, Uzer GB, Zong X, Styner MA, Rubin J, Styner M. Diet-Stimulated Marrow Adiposity Fails to Worsen Early, Age-Related Bone Loss. Obes Facts. 2024;17(2):145-157. PubMed Central ID: PMC10987189.
  15. Enrriques AE, Howard S, Timsina R, Khadka NK, Hoover AN, Ray AE, Ding L, Onwumelu C, Nordeng S, Mainali L, Uzer G, Davis PH. Atomic Force Microscopy Cantilever-Based Nanoindentation: Mechanical Property Measurements at the Nanoscale in Air and Fluid. J Vis Exp. 2022 Dec 2;(190) PubMed Central ID: PMC10141700.
  16. Sen B, Xie Z, Howard S, Styner S, Wijnen AjW, Uzer G, Rubin J, Mechanically Induced Nuclear Shuttling of β-Catenin Requires Co-transfer of Actin, Stem Cells, https://doi.org/10.1093/stmcls/sxac006, 2022
  17. Kennedy Z, Newberg J, Goelzer M, Fitzpatrick C, Uzer G. Modeling stem cell nucleus mechanics using confocal microscopy, Biomechanics and Modeling in Mechanobiology, doi.org/10.1007/s10237-021-01513-w, 2021
  18. Goelzer M, Goelzer J, Ferguson, ML, Neu CP, Uzer G Nuclear envelope mechanobiology: linking the nuclear structure and function. Nucleus (Austin, Tex.) 12, 90-114, doi:10.1080/19491034.2021.1962610, 2021.
  19. Goelzer M, Dudakovic A, Olcum M, Sen B, Ozcivici E, Rubin J, van Wijnen, A. J, Uzer, G. Lamin A/C Is Dispensable to Mechanical Repression of Adipogenesis. International Journal of Molecular Sciences, 22, (12), 6580, 2021
  20. Birks S, Uzer G. At the nuclear envelope of bone mechanobiology. Bone, 151, 116023, 2021
  21. Thompson M, Woods K, Newberg J, Oxford JT, Uzer G, Low Intensity Vibration Restores Nuclear YAP Levels and Acute YAP Nuclear Shuttling in Mesenchymal Stem Cells Subjected to Simulated Microgravity, NPJ Microgravity, 6(35), 2020.
  22. Yi X, Wright LE, Pagnotti GM, Uzer G, Powell KM, Wallace J, Sankar U, Rubin CT, Mohammad K, Guise TA, Thompson WR, Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling Requires Nucleo-Cytoskeletal Connectivity, Bone Research 8(40),  2020.
  23. Newberg J, Schimpf J, Woods K, Loisate S, Davis PHD, Uzer G, Isolated Nuclei Stiffen in Response to Low Intensity Vibration, Journal of Biomechanics, 111(9), 2020.
  24. Bas G, Loisate S, Hudon SF, Woods K, Hayden E, Pu X, Beard R, Oxford JT, Uzer G, Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation and Differentiation Capacity during in vitro Expansion, Scientific Reports 10, 9369, 2020.
  25. Goelzer M, Thompson W R, Uzer G, Cells as strain gages and load cells. Mechanobiology (ed Glen L. Niebur), p.79-98, Elsevier, 2020.
  26. Sankaran J, Sen B, Dudakovic B, Perdue T, Xie Z, Mcgrath C, Styner M, Newberg J, Uzer G, Wijnen AJ, Rubin J.  Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells, Stem Cells, 2020
  27. Sen B, Paradise CR, Xie Z, Sankaran J, Uzer G, Styner M, Meyer M, Dudakovic A, van Wijnen AJ, Rubin J. β-Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2, J Bone Miner Res, 35(6), p.1149-1162, 2020
  28. Touchstone H, Byrd R, Loisate S, Thompson M, Kim S, Senthilnathan A, Pu XS, Beard R, Rubin J, Alwood J, Oxford JT, Uzer G, Recovery of stem cell proliferation by low intensity vibration under simulated microgravity requires intact LINC complex, NPJ Microgravity, 5(11), 2019
  29. Sankaran J, Uzer G, van Wijnen AJ, Rubin J. Gene regulation through dynamic actin control of nuclear structure. Exp Biol Med, 244(15), p.1345-1353,  2019
  30. Pagnotti GM, Styner M, Uzer G, Patel V, Wright LE, PhD; Ness KK, Guise TA, Rubin J, Rubin CT. Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity, Nature Reviews Endocrinology, Vol. 15(6), p.339-355, 2019
  31. Uzer G, Bas G, Sen B, Xie Z, Birks S, Olcum M, McGrath C, Styner M, Rubin J., Sun-mediated Mechanical LINC between Nucleus and Cytoskeleton Regulates βcatenin Nuclear Access, Journal of Biomechanics, Vol. 74(6) p.32-40, 2018
  32. Graham DM, Andersen T, Sharek L, Uzer G, Rothenberg K, Hoffman BD, Rubin J, Balland M, Bear J and Burrdge K. Enucleated cells reveal differential roles of the nucleus in cell migration, polarity and mechanotransduction. Journal of Cell Biology, Vol. 217(3) p.895-914, 2018
  33. Rubin J, Styner M, Uzer G. Physical Signals May Affect Mesenchymal Stem Cell Differentiation Via Epigenetic Controls. Exerc Sport Sci Rev. Vol.46(1) p.42-47, 2018
  34. Thompson WR, Yen S, Uzer G, Xie Z, Sen B, Styner M, Burridge K, Rubin J. LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage. Bone Vol.107 (2) p.172-180, 2018
  35. Sen B, Uzer G, Samsonraj RM, Xie Z, McGrath C, Styner M, Dudakovic A, van Wijnen AJ, Rubin J. Intranuclear Actin Structure Modulates Mesenchymal Stem Cell Differentiation. Stem Cells. Vol. 35(6) p.1624-1635, 2017
  36. Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, Xie Z, Zong X, Styner MA, Rubin CT, Rubin J. Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice. J Bone Miner Res. Vol. 32(8), p.1692-1702, 2017
  37. Uzer G, Pongkitwitoon, Rubin J, Judex S, Cytoskeletal Configuration Modulates Mechanically Induced Changes in Mesenchymal Stem Cell Osteogenesis, Morphology and Stiffness, Scientific Reports, Oct;6:34791 , 2016
  38. Uzer G, Rubin CT, Rubin J, Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex, Current Molecular Biology Reports, Vol. 2(1), p. 36, 2016
  39. Uzer G, Fuchs RK, Rubin J, Thompson WR, Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage, Stem Cells Vol. 34(6), p. 1455, 2016, Front Endocrinol, Vol.30(7):80, eCollection, 2016
  40. Sen B, Uzer G, Xie Z, C McGrath, Styner M, Dudakovic A, Samsonraj R, van Wijnen AJ, Rubin J Intranuclear actin structure modulates MSC differentiation, Stem Cells Vol. 33(10), p.3065-76, 2016
  41. Morton TL, Galior K, McGrath C, Wu X, Uzer G, Uzer GB, Sen B, Xie Z, Tyson D, Rubin J, Styner M, Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice, 2016.
  42. Uzer G, Thompson WR, Xie Z, Sen B, Judex S, Rubin CT, Burridge K, Rubin J, Cell mechanosensitivity to extremely low magnitude signals is enabled by a LINCed nucleus, Stem Cells, Vol. 33(6), p. 2063, 2015
  43. Thompson WR, Uzer G, Yen S, Xie Z, Sen B, Case N, Styner M, Rubin J. A Novel Osteocyte Specific Responses to Soluble and Mechanical Stimuli in a Stem Cell Derived Culture Model, Scientific Reports.  Vol. 5, p. 11049, 2015
  44. Sen B, Xie Z, Uzer G,  Thompson WR, Styner M, Rubin J. Intranuclear Actin Regulates Osteogenesis, Stem Cells. Stem Cells, Vol. 33(10), p. 3065, 2015.
  45. Styner M, Wu X, Uzer G, Thompson WR, Sen B, Xie Z, Styner MA, Rubin J, Exercise regulation of marrow fat in the setting of PPAR-γ agonist treatment, Endocrinology. Vol. 156(8), p.2753-2761, 2015.
  46. Uzer G, Pongkitwitoon S, Chan ME, Rubin J, Judex S, Gap Junctional Communication in Osteocytes is Amplified by Low Intensity Vibrations in vitro, PLoS One, Vol. 9(3): e90840, 2014
  47. Styner M, Kadari S, Galior K, Uzer G, Thompson WR, Case N, Sen B, Xie Z, Romaine A, Styner MA, Pagnotti G, Rubin CT, Horowitz M, Rubin J, Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise, Bone,  Vol. 64, p. 39, 2014
  48. Sen B, Xie Z, Case N, Thompson WR, Uzer G, Styner M, Rubin J, mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow derived mesenchymal stem cells, Journal of Bone and Mineral Research, Vol. 29(1), p. 78, 2014
  49. Uzer G, Chan ME, Pongkitwitoon S, Judex S, Vibration Induced Osteogenic Commitment of Mesenchymal Stem Cells is Enhanced by Cytoskeletal Remodeling but not Fluid Shear, Journal of Biomechanics, Vol. 46(13),p.2296, 2013
  50. Thompson WR, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, Uzer G, Styner M, Case N, Burridge K, Rubin J, Mechanically Activated Fyn Utilizes mTORC2 to Regulate RhoA and Adipogenesis in Mesenchymal Stem Cells, Stem Cells ,Vol. 31(11),p. 2528, 2013
  51. Chan ME, Uzer G, Rubin CT,  The Potential Benefits and Inherent Risks of Vibration as a Non-Drug Therapy for the Prevention and Treatment of Osteoporosis, Current Osteoporosis Reports, Vol.11(1), p. 36, 2013
  52. Uzer G, Manske S, Chan ME, Chiang FP, Rubin CT, Frame MD, Judex S, Separating Fluid Shear Stress from Acceleration during Vibrations in Vitro: Identification of Mechanical Signals Modulating the Cellular Response, Cellular and Molecular Bioengineering, Vol. 5(3), p. 266, 2012
  53. Gupta S, Uzer G, Surabhi P, Judex S, Multiple Exposures to Unloading Decrease Bone’s Responsivity but Compound Skeletal Losses in C57BL/6 Mice American Journal of Physiology- Regulatory, Integrative and Comparative Physiology, Vol. 303(2), p.159, 2012
  54. Holguin N, Uzer G, Chiang FP, Rubin C, Judex S, A Brief Daily Exposure to Low Intensity Vibration Mitigates the Degradation of the Intervertebral Disc in a Frequency-specific Manner, Journal of Applied Physiology, Vol.111(6), p. 1846, 2011
  55. Uzer G and Chiang FP, Mapping Full Field Deformation of Auxetic Foams using Digital Speckle Photography, Physica Status Solidi B, Vol.245(11), p. 2391, 2008
  56. Uzer G, Chiang FP, Krukenkamp IB, Measuring Shape and Surface Strain of 3D Objects Using Digital Speckle Photography, Strain, Vol.45(5), p 409, 2008