Publications

Sen B, Xie Z, Howard S, Styner M, van Wijnen AJ, Uzer G,  Rubin J. Mechanically induced nuclear shuttling of β-catenin requires co-transfer of actin, Preprint available on bioRxiv at: org/10.1101/2021.11.22.469581

Goelzer M, Goelzer J, Ferguson, ML, Neu CP, Uzer G Nuclear envelope mechanobiology: linking the nuclear structure and function. Nucleus (Austin, Tex.) 12, 90-114, doi:10.1080/19491034.2021.1962610, 2021.

Kennedy Z, Newberg J, Goelzer M, Fitzpatrick C, Uzer G. Modeling stem cell nucleus mechanics using confocal microscopy, Biomechanics and Modeling in Mechanobiology, https://doi.org/10.1007/s10237-021-01513-w, 2021.

Goelzer M, Dudakovic A, Olcum M, Sen B, Ozcivici E, Rubin J, van Wijnen, A. J, Uzer, G. Lamin A/C Is Dispensable to Mechanical Repression of Adipogenesis. International Journal of Molecular Sciences, 22, (12), 6580, 2021

Birks S, Uzer G. At the nuclear envelope of bone mechanobiology. Bone, 151, 116023, 2021

Thompson M, Woods K, Newberg J, Oxford JT, Uzer G, Low Intensity Vibration Restores Nuclear YAP Levels and Acute YAP Nuclear Shuttling in Mesenchymal Stem Cells Subjected to Simulated Microgravity, NPJ Microgravity, 6(35), 2020.

Yi X, Wright LE, Pagnotti GM, Uzer G, Powell KM, Wallace J, Sankar U, Rubin CT, Mohammad K, Guise TA, Thompson WR, Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling Requires Nucleo-Cytoskeletal Connectivity, Bone Research 8(40),  2020.

Newberg J, Schimpf J, Woods K, Loisate S, Davis PHD, Uzer G, Isolated Nuclei Stiffen in Response to Low Intensity Vibration, Journal of Biomechanics, 111(9), 2020.

Bas G, Loisate S, Hudon SF, Woods K, Hayden E, Pu X, Beard R, Oxford JT, Uzer G, Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation and Differentiation Capacity during in vitro Expansion, Scientific Reports 10, 9369, 2020.

Goelzer M, Thompson W R, Uzer G, Cells as strain gages and load cells. Mechanobiology (ed Glen L. Niebur), p.79-98, Elsevier, 2020.

Sankaran J, Sen B, Dudakovic B, Perdue T, Xie Z, Mcgrath C, Styner M, Newberg J, Uzer G, Wijnen AJ, Rubin J.  Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells, Stem Cells, 2020

Sen B, Paradise CR, Xie Z, Sankaran J, Uzer G, Styner M, Meyer M, Dudakovic A, van Wijnen AJ, Rubin J. β-Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2, J Bone Miner Res, 35(6), p.1149-1162, 2020

Touchstone H, Byrd R, Loisate S, Thompson M, Kim S, Senthilnathan A, Pu XS, Beard R, Rubin J, Alwood J, Oxford JT, Uzer G, Recovery of stem cell proliferation by low intensity vibration under simulated microgravity requires intact LINC complex, NPJ Microgravity, 5(11), 2019

Sankaran J, Uzer G, van Wijnen AJ, Rubin J. Gene regulation through dynamic actin control of nuclear structure. Exp Biol Med, 244(15), p.1345-1353,  2019

Pagnotti GM, Styner M, Uzer G, Patel V, Wright LE, PhD; Ness KK, Guise TA, Rubin J, Rubin CT. Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity, Nature Reviews Endocrinology, Vol. 15(6), p.339-355, 2019

Uzer G, Bas G, Sen B, Xie Z, Birks S, Olcum M, McGrath C, Styner M, Rubin J., Sun-mediated Mechanical LINC between Nucleus and Cytoskeleton Regulates βcatenin Nuclear Access, Journal of Biomechanics, Vol. 74(6) p.32-40, 2018

Graham DM, Andersen T, Sharek L, Uzer G, Rothenberg K, Hoffman BD, Rubin J, Balland M, Bear J and Burrdge K. Enucleated cells reveal differential roles of the nucleus in cell migration, polarity and mechanotransduction. Journal of Cell Biology, Vol. 217(3) p.895-914, 2018

Rubin J, Styner M, Uzer G. Physical Signals May Affect Mesenchymal Stem Cell Differentiation Via Epigenetic Controls. Exerc Sport Sci Rev. Vol.46(1) p.42-47, 2018

Thompson WR, Yen S, Uzer G, Xie Z, Sen B, Styner M, Burridge K, Rubin J. LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage. Bone Vol.107 (2) p.172-180, 2018

Sen B, Uzer G, Samsonraj RM, Xie Z, McGrath C, Styner M, Dudakovic A, van Wijnen AJ, Rubin J. Intranuclear Actin Structure Modulates Mesenchymal Stem Cell Differentiation. Stem Cells. Vol. 35(6) p.1624-1635, 2017

Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, Xie Z, Zong X, Styner MA, Rubin CT, Rubin J. Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice. J Bone Miner Res. Vol. 32(8), p.1692-1702, 2017

Uzer G, Pongkitwitoon, Rubin J, Judex S, Cytoskeletal Configuration Modulates Mechanically Induced Changes in Mesenchymal Stem Cell Osteogenesis, Morphology and Stiffness, Scientific Reports, Oct;6:34791 , 2016

Uzer G, Rubin CT, Rubin J, Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex, Current Molecular Biology Reports, Vol. 2(1), p. 36, 2016

Uzer G, Fuchs RK, Rubin J, Thompson WR, Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage, Stem Cells Vol. 34(6), p. 1455, 2016, Front Endocrinol, Vol.30(7):80, eCollection, 2016

Sen B, Uzer G, Xie Z, C McGrath, Styner M, Dudakovic A, Samsonraj R, van Wijnen AJ, Rubin J Intranuclear actin structure modulates MSC differentiation, Stem Cells Vol. 33(10), p.3065-76, 2016

Morton TL, Galior K, McGrath C, Wu X, Uzer G, Uzer GB, Sen B, Xie Z, Tyson D, Rubin J, Styner M, Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice, 2016.

Uzer G, Thompson WR, Xie Z, Sen B, Judex S, Rubin CT, Burridge K ,Rubin J, Cell mechanosensitivity to extremely low magnitude signals is enabled by a LINCed nucleus, Stem Cells, Vol. 33(6), p. 2063, 2015

Thompson WR, Uzer G, Yen S, Xie Z, Sen B, Case N, Styner M, Rubin J. A Novel Osteocyte Specific Responses to Soluble and Mechanical Stimuli in a Stem Cell Derived Culture Model, Scientific Reports.  Vol. 5, p. 11049, 2015

Sen B, Xie Z, Uzer G,  Thompson WR, Styner M, Rubin J. Intranuclear Actin Regulates Osteogenesis, Stem Cells. Stem Cells, Vol. 33(10), p. 3065, 2015.

Styner M, Wu X, Uzer G, Thompson WR, Sen B, Xie Z, Styner MA, Rubin J, Exercise regulation of marrow fat in the setting of PPAR-γ agonist treatment, Endocrinology. Vol. 156(8), p.2753-2761, 2015.

Uzer G, Pongkitwitoon S, Chan ME, Rubin J, Judex S ,Gap Junctional Communication in Osteocytes is Amplified by Low Intensity Vibrations in vitro, PLoS One, Vol. 9(3): e90840, 2014

Styner M, Kadari S, Galior K, Uzer G, Thompson WR, Case N, Sen B, Xie Z, Romaine A, Styner MA, Pagnotti G, Rubin CT, Horowitz M, Rubin J, Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise, Bone,  Vol. 64, p. 39, 2014

Sen B, Xie Z, Case N, Thompson WR, Uzer G, Styner M, Rubin J, mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow derived mesenchymal stem cells, Journal of Bone and Mineral Research, Vol. 29(1), p. 78, 2014

Uzer G, Chan ME, Pongkitwitoon S, Judex S, Vibration Induced Osteogenic Commitment of Mesenchymal Stem Cells is Enhanced by Cytoskeletal Remodeling but not Fluid Shear, Journal of Biomechanics, Vol. 46(13),p.2296, 2013

Thompson WR, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, Uzer G, Styner M, Case N, Burridge K, Rubin J, Mechanically Activated Fyn Utilizes mTORC2 to Regulate RhoA and Adipogenesis in Mesenchymal Stem Cells, Stem Cells ,Vol. 31(11),p. 2528, 2013

Chan ME, Uzer G, Rubin CT,  The Potential Benefits and Inherent Risks of Vibration as a Non-Drug Therapy for the Prevention and Treatment of Osteoporosis, Current Osteoporosis Reports, Vol.11(1), p. 36, 2013

Uzer G, Manske S, Chan ME, Chiang FP, Rubin CT, Frame MD, Judex S, Separating Fluid Shear Stress from Acceleration during Vibrations in Vitro: Identification of Mechanical Signals Modulating the Cellular Response, Cellular and Molecular Bioengineering, Vol. 5(3), p. 266, 2012

Gupta S, Uzer G, Surabhi P, Judex S, Multiple Multiple Exposures to Unloading Decrease Bone’s Responsivity but Compound Skeletal Losses in C57BL/6 Mice American Journal of Physiology- Regulatory, Integrative and Comparative Physiology, Vol. 303(2), p.159, 2012

Holguin N, Uzer G, Chiang FP, Rubin C, Judex S, A Brief Daily Exposure to Low Intensity Vibration Mitigates the Degradation of the Intervertebral Disc in a Frequency-specific Manner, Journal of Applied Physiology, Vol.111(6), p. 1846, 2011

Uzer G and Chiang FP, Mapping Full Field Deformation of Auxetic Foams using Digital Speckle Photography, Physica Status Solidi B, Vol.245(11), p. 2391, 2008

Uzer G, Chiang FP, Krukenkamp IB, Measuring Shape and Surface Strain of 3D Objects Using Digital Speckle Photography, Strain, Vol.45(5), p 409, 2008