Don L. Warner, Ph.D.

What courses would you recommend students have taken prior to working in your laboratory?

General Chemistry

How many hours per week do you expect a student to spend in the laboratory per research credit and does the time have to be a set schedule?

10 hours per week, per credit. The student’s schedule can be flexible, however once the student chooses their schedule, it is set for the semester.

Ideally, for what length of time would a student research in your laboratory to achieve a meaningful research experience?

3 – 4 semesters

• 2002: Ph.D. – Chemistry | University of Michigan
• 1998: M.S. – Chemistry | University of Wisconsin
• 1995: B.S. | University of Utah

Recently, our research interests have focused on the topics listed below:

• Synthesis of Small Molecules for Inhibition of Pro-Metastatic Cytokines
• Synthesis of Cytotoxic Anticancer Agents
• Mechanistic Studies of and Related to Anticancer Agents
• Impact of Research Experiences on Student Learning

PEER-REVIEWED PUBLICATIONS (*Undergraduates; †Graduate Students)

1. “Cultivating a New “SEED”: From an On-Ground to Online Chemistry Summer Camp” Nadelson, L. S.; Jemison, R. C.; †Soto, E.; Warner, D. L. J. Chem. Educ. 2022, 99, 129–139, https://doi.org/10.1021/acs.jchemed.1c00280.
2. “Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery” Mass, O. A.; *Tuccinardi, J.; Woodbury, L.; †Wolf, C. L.; *Grantham, B.; †Holdaway, K.; Pu, X.; King, M. D.; Warner, D. L.; Jorcyk, C. L.; Warner, L. R. Sci. Rep. 2021 11, 16174 https://doi.org/10.1038/s41598-021-95424-6.
3. “Center of Biomedical Research Excellence in Matrix Biology: Building Research Infrastructure, Supporting Young Researchers, and Fostering Collaboration” Oxford, J. T., … Warner, D. L. et al. Int. J. Mol. Sci. 2020, 21, 2141.
4. “Better Together: Connecting with Other Disciplines Builds Students’ Own Skills and Professional Identity” Llewellyn, D. C.; Pyke, P.; Paterson, S.; Landrum, R. E.; Scarritt, A.; Cullers, J. B. S.; Warner, D. L. (2016, June) Paper presented at 2016 ASEE Annual Conference & Exposition, New Orleans, Louisiana. 10.18260/p.26381.
5. “Laboratory Instrumentation: An Exploration of the Impact of Instrumentation on Student Learning” Warner, D. L.; Brown, E. C.; Shadle, S. E. J. Chem. Educ. 2016, 93, 1223-1231.
6. “Modification of Cellular DNA by Synthetic Aziridinomitosenes” †Mallory, C. M.; *Carfi, R. P.; †Moon, S.; Cornell, K. A.; Warner, D. L. Biorg. Med. Chem. 2015, 23(23), 7378-7385.
7. “Life’s Lessons in the Lab: A Summer of Learning from Undergraduate Research Experiences” Nadelson, L. S.; Warner, D. L.; Brown, E. J. STEM Education 2015, 16(3), 5-12.
8. “Modeling Sₙ2 and E2 Reaction Pathways and other Computational Exercises in the Undergraduate Organic Chemistry Laboratory” *Csizmar, C.; *Daniels, J. P.; *Davis, L. E.; *Hoovis, T. P.; Hammond, K. A.; McDougal, O. M.; Warner, D. L. J. Chem. Educ. 2013, 90, 1235-1238.
9. “A Green Approach to Separate Spinach Pigments by Column Chromatography” *Johnston, A.; Scaggs, J.; *Mallory, C.; Haskett, A.; Warner, D. L.; Brown, E.; Hammond, K.; McCormick, M.; McDougal, O. J. Chem. Educ. 2013, 90, 796-798.
10. “A Rubric for Assessing Students’ Experimental Problem-Solving Ability” Shadle, S.; Brown, E.; Towns, M.; Warner, D. L. J. Chem. Educ. 2012, 89, 319-325.
11. “Examination of Bond Properties through Infrared Spectroscopy and Molecular Modeling in the General Chemistry Laboratory” *Csizmar, C.; Force, D. A.; Warner, D. L. J. Chem. Educ. 2012, 89, 379-382.
12. “Recycling of Waste Acetone by Fractional Distillation” *Weires, N. A.; *Johnston, A.; Warner, D. L.; McCormick, M. M.; Hammond, K.; McDougal, O. M. J. Chem. Educ. 2011, 88, 1724-1726.
13. “Implementation of Gas Chromatography and Microscale Distillation into the General Chemistry Laboratory Curriculum as Vehicles for Examining Intermolecular Forces” *Csizmar, C.; Force, D. A.; Warner, D. L. J. Chem. Educ. 2011, 88, 966-969.
14. “Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione Derivatives and their Biological Activities on Human Liver Carbonyl Reductase” Berhe, S.; *Slupe, A.; *Luster, C.; Charlier, H. A., Jr.; Warner, D. L.; Zalkow, L. H.; Burgess, E. M.; Enwerem, N. M.; Bakare, O. Bioorganic & Medicinal Chemistry 2010, 18, 134-141.
15. “Internal Azomethine Ylide Cycloaddition Methodology Leading to the Substitution Pattern of Aziridinomitosene A” Bobeck, D. R.; Warner, D. L.; Vedejs, E. J. Org. Chem. 2007, 72, 8506.
16. “N-Silyl Protecting Groups for Labile Aziridines: Application Toward the Synthesis of N-H Aziridinomitosenes” Warner, D. L.; *Hibberd, A. M.; *Kalman, M.; Klapars, A.; Vedejs, E. J. Org. Chem. 2007, 72, 8519.
17. “Reduction of 13-Deoxydoxorubicin and Daunorubicinol Anthraquinones by Human Carbonyl Reductase” *Slupe, A.; *Williams, B.; *Larson, C.; *Lee, L. M.; *Primbs, T.; *Bruesch, A. J.; *Bjorklund, C.; Warner, D. L.; Peloquin, J.; Shadle, S. E.; Gambliel, H. A.; Cusack, B. J.; Olson, R. D.; Charlier, Jr., H.A. Cardiovascular Toxicology 2005, 5, 365.
18. “Sequence-Specific DNA Interstrand Cross-Linking by an Aziridinomitosene in the Absence of Exogenous Reductant” Rink, S. M.; Warner, D. L.; Klapars, A.; Vedejs, E. Biochemistry 2005, 44, 13981.
19. “Synthetic Enantiopure Aziridinomitosenes; Preparation, Reactivity, and DNA Alkylation Studies” Vedejs, E.; Naidu, B. N.; Klapars, A.; Warner, D. L.; Li, V-s.; Na, Y.; Kohn, H. J. Am. Chem. Soc. 2003, 125, 15796.
20. “Reductive Deprotection of N-Trityl Aziridines” Vedejs, E.; Klapars, A.; Warner, D. L.; *Weiss, A. J. Org. Chem. 2001, 66, 7542.

ARTICLES AND EDITORIALS IN NATIONAL PUBLICATIONS

1. “Opportunities for Growth Through Engagement in Summer Research” Warner, D. L. Chemistry Solutions 2024 (November); https://teachchemistry.org/periodical/issues/november-2024.
2. “Engaging Students Through Chemistry Research” Warner, D. L. Chemistry Solutions 2023 (November); https://teachchemistry.org/periodical/issues/november-2023.
3. “Project SEED hosts a virtual summer camp” Warner, D. L. C&E News 2020, 98(29), 37.
4. “ACS Project SEED: The next 50 years” Warner, D. L. C&E News 2019, 97(36), 40.
5. “Celebrating Project SEED’s impact” Warner, D. L. C&E News 2018, 96(11), 49.

PATENTS

“Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use” King, M. D.; Warner, L. R.; Warner, D. L.; Jorcyk, C. L. 2023; US Patent 11633457.

2022-2025 “Small Molecule Inhibitors of the Inflammatory Cytokine Oncostatin M”; National Institutes of Health-National Cancer Institute; 04/22-03/25; role: PI.

2022-2023 “Solving NMR structures for OSM bound to novel OSM-small molecule inhibitors to develop improved compounds for the inhibition of breast cancer metastasis”; University of Washington Institute of Translational Health Sciences; role: Co-PI (L. Warner, PI)

2018-2022 “High impact therapeutic for the elimination of breast cancer metastasis to bone”; METAvivor. The Quinn-Davis Northwest Arkansas METSquerade Fund Research Award; role: Co-PI (Jorcyk, PI)

Idaho INBRE Pilot Project Warner – INBRE – U of I

Recognized 8 times as a Boise State University “Top Ten Scholars Honored Faculty Member”

• 2022 American Chemical Society Fellow
• 2022 Boise Rotary Century Scholar’s “Significant Educator”
• 2017: Boise State Foundation Scholar Award for Teaching
• 2014: College of Arts and Sciences Award for Distinguished Teaching
• 2010: ASBSU (Boise State student government) Golden Apple Award for the Arts and Sciences
• 2007: Provost’s Excellence in Advising Award for the College of Arts and Sciences
• 2004: ASBSU Student’s Choice Outstanding Faculty Member for the College of Arts and Sciences
• 2003: ASBSU Student’s Choice Outstanding Faculty Member for the College of Arts and Sciences
• 2001: Hoffmann-La Roche Award for Excellence in Organic Chemistry
• 2001: Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry