To the right information regarding our COBRE Research and Investigators specific projects. Below is Allan Albig’s, the lead investigator, project summary. His project focuses on new studies and discoveries regarding the MGP protein.
Albig’s Project Summary:
Intro
Abnormal extracellular matrix mineralization is associated with some of the most prevalent and deadly diseases of western societies. This includes atherosclerosis and arteriosclerosis. Because of this, understanding the molecular mechanisms by which abnormal matrix mineralization proceeds is an important first step toward better treatment for these diseases. Matrix Gla Protein (MGP) is an extracellular matrix protein that is a powerful suppressor of tissue mineralization.
MGP
MGP knockout mice develop extreme aortic calcification. As well as MGP polymorphisms in humans is associated with increased risk of developing arterial calcification. Despite the important role of MPG in preventing vascular mineralization, the molecular mechanisms by which MGP expression is controlled and by which MGP functions are only partly understood. Our preliminary data and published results have shown that MGP controls Notch signaling. Importantly, this signals the pathway that synergizes with Bone Morphogenetic Proteins to control vascular biology. This observation has opened a door that may lead us to a better understanding of the role of MGP in vascular health.
Claims
Before we end this proposal, we will examine two specific aims. First, we believe we have identified a previously unknown negative feedback mechanism. We hypothesize this serves an important role to control MGP expression and vascular extracellular matrix calcification. Second, we will continue to examine the molecular mechanism(s) by which MGP controls Notch signaling. Furthermore, it is an aspect of MGP function that we hypothesize is important for suppressing arterial matrix mineralization. Upon completion of these studies, we will arrive at a new understanding of the role of MGP in arterial health. Also, as a Junior Investigator in the COBRE in Matrix Biology, I will work with my scientific mentor to complete the scientific aims and to develop a grant proposal for future R01 funding.
For more information about Dr. Allan Albig, please visit the Department of Biological Sciences webpage. Along with that, information regarding different COBRE Research and Investigators, look to the right.